Serveur d'exploration Chloroquine

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Cardiopulmonary effects of antimalarial drugs

Identifieur interne : 003B96 ( Main/Exploration ); précédent : 003B95; suivant : 003B97

Cardiopulmonary effects of antimalarial drugs

Auteurs : Ruy Ruiz [États-Unis] ; Michael Belej [États-Unis] ; Domingo M. Aviado [États-Unis]

Source :

RBID : ISTEX:D10563BF9501780F3F3357EE84369043EA2A4E45

Descripteurs français

English descriptors

Abstract

Abstract: WR 33,063 has the chemical name: 6-bromo-α-(diheptylaminomethyl)-9-phenanthrenemethanol. It does not influence the cardiac output, blood pressure and pulmonary resistance in anesthetized dogs. It does not influence pulmonary resistance or blood pressure in anesthetized rabbits. The compound depresses the excitability of the heart of mice in response to inhalation of chloroform. There are no important changes in contents of biogenic amines in the lung, heart, and brain of mice and rabbits that receive doses less than 100 mg/kg of WR 33,063. The other phenanthrenemethanol which has been previously investigated in man is NIH 204; it has the following chemical name: α-(diamylaminomethyl)-1,2,3,4-tetrahydro-9-phenanthrenemethanol. This compound produces an increase in pulmonary resistance in anesthetized rabbits and dogs. It also increases cardiac output in dogs by releasing catecholamines. The mechanism for the previously reported sympathomimetic effect of NIH 204 in man has been identified in the experiments in dogs; this compound causes a release of catecholamines.

Url:
DOI: 10.1016/0041-008X(70)90137-7


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title>Cardiopulmonary effects of antimalarial drugs</title>
<author>
<name sortKey="Ruiz, Ruy" sort="Ruiz, Ruy" uniqKey="Ruiz R" first="Ruy" last="Ruiz">Ruy Ruiz</name>
</author>
<author>
<name sortKey="Belej, Michael" sort="Belej, Michael" uniqKey="Belej M" first="Michael" last="Belej">Michael Belej</name>
</author>
<author>
<name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D10563BF9501780F3F3357EE84369043EA2A4E45</idno>
<date when="1970" year="1970">1970</date>
<idno type="doi">10.1016/0041-008X(70)90137-7</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-9JQ309C4-5/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C23</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C23</idno>
<idno type="wicri:Area/Istex/Curation">000C23</idno>
<idno type="wicri:Area/Istex/Checkpoint">002932</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002932</idno>
<idno type="wicri:doubleKey">0041-008X:1970:Ruiz R:cardiopulmonary:effects:of</idno>
<idno type="wicri:Area/Main/Merge">003C78</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:5456630</idno>
<idno type="wicri:Area/PubMed/Corpus">000653</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000653</idno>
<idno type="wicri:Area/PubMed/Curation">000653</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000653</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000626</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000626</idno>
<idno type="wicri:Area/Ncbi/Merge">001098</idno>
<idno type="wicri:Area/Ncbi/Curation">001098</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001098</idno>
<idno type="wicri:doubleKey">0041-008X:1970:Ruiz R:cardiopulmonary:effects:of</idno>
<idno type="wicri:Area/Main/Merge">003C67</idno>
<idno type="wicri:Area/Main/Curation">003B96</idno>
<idno type="wicri:Area/Main/Exploration">003B96</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a">Cardiopulmonary effects of antimalarial drugs</title>
<author>
<name sortKey="Ruiz, Ruy" sort="Ruiz, Ruy" uniqKey="Ruiz R" first="Ruy" last="Ruiz">Ruy Ruiz</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Belej, Michael" sort="Belej, Michael" uniqKey="Belej M" first="Michael" last="Belej">Michael Belej</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name>
<affiliation wicri:level="2">
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Toxicology and Applied Pharmacology</title>
<title level="j" type="abbrev">YTAAP</title>
<idno type="ISSN">0041-008X</idno>
<imprint>
<publisher>ELSEVIER</publisher>
<date type="published" when="1970">1970</date>
<biblScope unit="volume">17</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="118">118</biblScope>
<biblScope unit="page" to="129">129</biblScope>
</imprint>
<idno type="ISSN">0041-008X</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0041-008X</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Anesthesia</term>
<term>Animals</term>
<term>Antimalarials (pharmacology)</term>
<term>Aorta (drug effects)</term>
<term>Blood Pressure (drug effects)</term>
<term>Brain Chemistry</term>
<term>Bronchi (drug effects)</term>
<term>Cardiac Output (drug effects)</term>
<term>Chloroform</term>
<term>Chloroquine (pharmacology)</term>
<term>Dopamine (analysis)</term>
<term>Electrocardiography</term>
<term>Heart (drug effects)</term>
<term>Histamine (analysis)</term>
<term>Lung (analysis)</term>
<term>Lung (drug effects)</term>
<term>Lung Compliance (drug effects)</term>
<term>Male</term>
<term>Methanol (pharmacology)</term>
<term>Mice</term>
<term>Myocardium (analysis)</term>
<term>Norepinephrine (analysis)</term>
<term>Phenanthrenes (pharmacology)</term>
<term>Rabbits</term>
<term>Serotonin (analysis)</term>
<term>Vascular Resistance (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Anesthésie</term>
<term>Animaux</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Aorte ()</term>
<term>Biochimie de l'encéphale</term>
<term>Bronches ()</term>
<term>Chloroforme</term>
<term>Chloroquine (pharmacologie)</term>
<term>Coeur ()</term>
<term>Compliance pulmonaire ()</term>
<term>Dopamine (analyse)</term>
<term>Débit cardiaque ()</term>
<term>Histamine (analyse)</term>
<term>Lapins</term>
<term>Myocarde (analyse)</term>
<term>Mâle</term>
<term>Méthanol (pharmacologie)</term>
<term>Norépinéphrine (analyse)</term>
<term>Phénanthrènes (pharmacologie)</term>
<term>Poumon ()</term>
<term>Poumon (analyse)</term>
<term>Pression sanguine ()</term>
<term>Résistance vasculaire ()</term>
<term>Souris</term>
<term>Sérotonine (analyse)</term>
<term>Électrocardiographie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en">
<term>Dopamine</term>
<term>Histamine</term>
<term>Norepinephrine</term>
<term>Serotonin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Antimalarials</term>
<term>Chloroquine</term>
<term>Methanol</term>
<term>Phenanthrenes</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr">
<term>Dopamine</term>
<term>Histamine</term>
<term>Myocarde</term>
<term>Norépinéphrine</term>
<term>Poumon</term>
<term>Sérotonine</term>
</keywords>
<keywords scheme="MESH" qualifier="analysis" xml:lang="en">
<term>Lung</term>
<term>Myocardium</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Aorta</term>
<term>Blood Pressure</term>
<term>Bronchi</term>
<term>Cardiac Output</term>
<term>Heart</term>
<term>Lung</term>
<term>Lung Compliance</term>
<term>Vascular Resistance</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Antipaludiques</term>
<term>Chloroquine</term>
<term>Méthanol</term>
<term>Phénanthrènes</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Airway resistance</term>
<term>Amine</term>
<term>Anesthesia</term>
<term>Anesthetized</term>
<term>Anesthetized dogs</term>
<term>Animals</term>
<term>Antiarrhythmic</term>
<term>Antiarrhythmic effect</term>
<term>Antiarrhythmic effects</term>
<term>Antimalarial</term>
<term>Antimalarial activity</term>
<term>Antimalarial drugs</term>
<term>Antimalarial survey</term>
<term>Aortic blood pressure</term>
<term>Arterial blood pressure</term>
<term>Aviado</term>
<term>Biogenic</term>
<term>Biogenic amines</term>
<term>Blood pressure</term>
<term>Brain Chemistry</term>
<term>Bronchopulmonary</term>
<term>Cardiac</term>
<term>Cardiac output</term>
<term>Chloroform</term>
<term>Chloroquine</term>
<term>Coatney</term>
<term>Continuous infusion</term>
<term>Control injection</term>
<term>Effect effect</term>
<term>Electrocardiography</term>
<term>Fibrillation</term>
<term>Heart rate</term>
<term>Histamine</term>
<term>Infusion</term>
<term>Infusion table</term>
<term>Intraduodenal administration</term>
<term>Lung tissue</term>
<term>Male</term>
<term>Methocel suspension</term>
<term>Mice</term>
<term>Mouse</term>
<term>National institutes</term>
<term>Other dogs</term>
<term>Other phenanthrenemethanol</term>
<term>Peak frequency</term>
<term>Phenanthrenemethanols</term>
<term>Polyethylene glycol</term>
<term>Pulmonary compliance</term>
<term>Pulmonary resistance</term>
<term>Rabbits</term>
<term>Sadavongvivad</term>
<term>Serotonin</term>
<term>Serotonin content</term>
<term>Serotonin level</term>
<term>Significant change</term>
<term>Therapeutic index</term>
<term>Total dose</term>
<term>Ventricular fibrillation</term>
<term>Vivax malaria</term>
<term>Walter reed army institute</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Anesthésie</term>
<term>Animaux</term>
<term>Aorte</term>
<term>Biochimie de l'encéphale</term>
<term>Bronches</term>
<term>Chloroforme</term>
<term>Coeur</term>
<term>Compliance pulmonaire</term>
<term>Débit cardiaque</term>
<term>Lapins</term>
<term>Mâle</term>
<term>Poumon</term>
<term>Pression sanguine</term>
<term>Résistance vasculaire</term>
<term>Souris</term>
<term>Électrocardiographie</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Abstract: WR 33,063 has the chemical name: 6-bromo-α-(diheptylaminomethyl)-9-phenanthrenemethanol. It does not influence the cardiac output, blood pressure and pulmonary resistance in anesthetized dogs. It does not influence pulmonary resistance or blood pressure in anesthetized rabbits. The compound depresses the excitability of the heart of mice in response to inhalation of chloroform. There are no important changes in contents of biogenic amines in the lung, heart, and brain of mice and rabbits that receive doses less than 100 mg/kg of WR 33,063. The other phenanthrenemethanol which has been previously investigated in man is NIH 204; it has the following chemical name: α-(diamylaminomethyl)-1,2,3,4-tetrahydro-9-phenanthrenemethanol. This compound produces an increase in pulmonary resistance in anesthetized rabbits and dogs. It also increases cardiac output in dogs by releasing catecholamines. The mechanism for the previously reported sympathomimetic effect of NIH 204 in man has been identified in the experiments in dogs; this compound causes a release of catecholamines.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Pennsylvanie</li>
</region>
</list>
<tree>
<country name="États-Unis">
<region name="Pennsylvanie">
<name sortKey="Ruiz, Ruy" sort="Ruiz, Ruy" uniqKey="Ruiz R" first="Ruy" last="Ruiz">Ruy Ruiz</name>
</region>
<name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name>
<name sortKey="Belej, Michael" sort="Belej, Michael" uniqKey="Belej M" first="Michael" last="Belej">Michael Belej</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B96 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B96 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:D10563BF9501780F3F3357EE84369043EA2A4E45
   |texte=   Cardiopulmonary effects of antimalarial drugs
}}

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021