Cardiopulmonary effects of antimalarial drugs
Identifieur interne : 003B96 ( Main/Exploration ); précédent : 003B95; suivant : 003B97Cardiopulmonary effects of antimalarial drugs
Auteurs : Ruy Ruiz [États-Unis] ; Michael Belej [États-Unis] ; Domingo M. Aviado [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1970.
Descripteurs français
- KwdFr :
- Anesthésie, Animaux, Antipaludiques (pharmacologie), Aorte (), Biochimie de l'encéphale, Bronches (), Chloroforme, Chloroquine (pharmacologie), Coeur (), Compliance pulmonaire (), Dopamine (analyse), Débit cardiaque (), Histamine (analyse), Lapins, Myocarde (analyse), Mâle, Méthanol (pharmacologie), Norépinéphrine (analyse), Phénanthrènes (pharmacologie), Poumon (), Poumon (analyse), Pression sanguine (), Résistance vasculaire (), Souris, Sérotonine (analyse), Électrocardiographie.
- MESH :
- analyse : Dopamine, Histamine, Myocarde, Norépinéphrine, Poumon, Sérotonine.
- pharmacologie : Antipaludiques, Chloroquine, Méthanol, Phénanthrènes.
- Anesthésie, Animaux, Aorte, Biochimie de l'encéphale, Bronches, Chloroforme, Coeur, Compliance pulmonaire, Débit cardiaque, Lapins, Mâle, Poumon, Pression sanguine, Résistance vasculaire, Souris, Électrocardiographie.
English descriptors
- KwdEn :
- Anesthesia, Animals, Antimalarials (pharmacology), Aorta (drug effects), Blood Pressure (drug effects), Brain Chemistry, Bronchi (drug effects), Cardiac Output (drug effects), Chloroform, Chloroquine (pharmacology), Dopamine (analysis), Electrocardiography, Heart (drug effects), Histamine (analysis), Lung (analysis), Lung (drug effects), Lung Compliance (drug effects), Male, Methanol (pharmacology), Mice, Myocardium (analysis), Norepinephrine (analysis), Phenanthrenes (pharmacology), Rabbits, Serotonin (analysis), Vascular Resistance (drug effects).
- MESH :
- chemical , analysis : Dopamine, Histamine, Norepinephrine, Serotonin.
- chemical , pharmacology : Antimalarials, Chloroquine, Methanol, Phenanthrenes.
- analysis : Lung, Myocardium.
- drug effects : Aorta, Blood Pressure, Bronchi, Cardiac Output, Heart, Lung, Lung Compliance, Vascular Resistance.
- Teeft :
- Airway resistance, Amine, Anesthesia, Anesthetized, Anesthetized dogs, Animals, Antiarrhythmic, Antiarrhythmic effect, Antiarrhythmic effects, Antimalarial, Antimalarial activity, Antimalarial drugs, Antimalarial survey, Aortic blood pressure, Arterial blood pressure, Aviado, Biogenic, Biogenic amines, Blood pressure, Brain Chemistry, Bronchopulmonary, Cardiac, Cardiac output, Chloroform, Chloroquine, Coatney, Continuous infusion, Control injection, Effect effect, Electrocardiography, Fibrillation, Heart rate, Histamine, Infusion, Infusion table, Intraduodenal administration, Lung tissue, Male, Methocel suspension, Mice, Mouse, National institutes, Other dogs, Other phenanthrenemethanol, Peak frequency, Phenanthrenemethanols, Polyethylene glycol, Pulmonary compliance, Pulmonary resistance, Rabbits, Sadavongvivad, Serotonin, Serotonin content, Serotonin level, Significant change, Therapeutic index, Total dose, Ventricular fibrillation, Vivax malaria, Walter reed army institute.
Abstract
Abstract: WR 33,063 has the chemical name: 6-bromo-α-(diheptylaminomethyl)-9-phenanthrenemethanol. It does not influence the cardiac output, blood pressure and pulmonary resistance in anesthetized dogs. It does not influence pulmonary resistance or blood pressure in anesthetized rabbits. The compound depresses the excitability of the heart of mice in response to inhalation of chloroform. There are no important changes in contents of biogenic amines in the lung, heart, and brain of mice and rabbits that receive doses less than 100 mg/kg of WR 33,063. The other phenanthrenemethanol which has been previously investigated in man is NIH 204; it has the following chemical name: α-(diamylaminomethyl)-1,2,3,4-tetrahydro-9-phenanthrenemethanol. This compound produces an increase in pulmonary resistance in anesthetized rabbits and dogs. It also increases cardiac output in dogs by releasing catecholamines. The mechanism for the previously reported sympathomimetic effect of NIH 204 in man has been identified in the experiments in dogs; this compound causes a release of catecholamines.
Url:
DOI: 10.1016/0041-008X(70)90137-7
Affiliations:
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Le document en format XML
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<author><name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia</term>
<term>Animals</term>
<term>Antimalarials (pharmacology)</term>
<term>Aorta (drug effects)</term>
<term>Blood Pressure (drug effects)</term>
<term>Brain Chemistry</term>
<term>Bronchi (drug effects)</term>
<term>Cardiac Output (drug effects)</term>
<term>Chloroform</term>
<term>Chloroquine (pharmacology)</term>
<term>Dopamine (analysis)</term>
<term>Electrocardiography</term>
<term>Heart (drug effects)</term>
<term>Histamine (analysis)</term>
<term>Lung (analysis)</term>
<term>Lung (drug effects)</term>
<term>Lung Compliance (drug effects)</term>
<term>Male</term>
<term>Methanol (pharmacology)</term>
<term>Mice</term>
<term>Myocardium (analysis)</term>
<term>Norepinephrine (analysis)</term>
<term>Phenanthrenes (pharmacology)</term>
<term>Rabbits</term>
<term>Serotonin (analysis)</term>
<term>Vascular Resistance (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anesthésie</term>
<term>Animaux</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Aorte ()</term>
<term>Biochimie de l'encéphale</term>
<term>Bronches ()</term>
<term>Chloroforme</term>
<term>Chloroquine (pharmacologie)</term>
<term>Coeur ()</term>
<term>Compliance pulmonaire ()</term>
<term>Dopamine (analyse)</term>
<term>Débit cardiaque ()</term>
<term>Histamine (analyse)</term>
<term>Lapins</term>
<term>Myocarde (analyse)</term>
<term>Mâle</term>
<term>Méthanol (pharmacologie)</term>
<term>Norépinéphrine (analyse)</term>
<term>Phénanthrènes (pharmacologie)</term>
<term>Poumon ()</term>
<term>Poumon (analyse)</term>
<term>Pression sanguine ()</term>
<term>Résistance vasculaire ()</term>
<term>Souris</term>
<term>Sérotonine (analyse)</term>
<term>Électrocardiographie</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Dopamine</term>
<term>Histamine</term>
<term>Norepinephrine</term>
<term>Serotonin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term>
<term>Chloroquine</term>
<term>Methanol</term>
<term>Phenanthrenes</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Dopamine</term>
<term>Histamine</term>
<term>Myocarde</term>
<term>Norépinéphrine</term>
<term>Poumon</term>
<term>Sérotonine</term>
</keywords>
<keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Lung</term>
<term>Myocardium</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aorta</term>
<term>Blood Pressure</term>
<term>Bronchi</term>
<term>Cardiac Output</term>
<term>Heart</term>
<term>Lung</term>
<term>Lung Compliance</term>
<term>Vascular Resistance</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term>
<term>Chloroquine</term>
<term>Méthanol</term>
<term>Phénanthrènes</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Airway resistance</term>
<term>Amine</term>
<term>Anesthesia</term>
<term>Anesthetized</term>
<term>Anesthetized dogs</term>
<term>Animals</term>
<term>Antiarrhythmic</term>
<term>Antiarrhythmic effect</term>
<term>Antiarrhythmic effects</term>
<term>Antimalarial</term>
<term>Antimalarial activity</term>
<term>Antimalarial drugs</term>
<term>Antimalarial survey</term>
<term>Aortic blood pressure</term>
<term>Arterial blood pressure</term>
<term>Aviado</term>
<term>Biogenic</term>
<term>Biogenic amines</term>
<term>Blood pressure</term>
<term>Brain Chemistry</term>
<term>Bronchopulmonary</term>
<term>Cardiac</term>
<term>Cardiac output</term>
<term>Chloroform</term>
<term>Chloroquine</term>
<term>Coatney</term>
<term>Continuous infusion</term>
<term>Control injection</term>
<term>Effect effect</term>
<term>Electrocardiography</term>
<term>Fibrillation</term>
<term>Heart rate</term>
<term>Histamine</term>
<term>Infusion</term>
<term>Infusion table</term>
<term>Intraduodenal administration</term>
<term>Lung tissue</term>
<term>Male</term>
<term>Methocel suspension</term>
<term>Mice</term>
<term>Mouse</term>
<term>National institutes</term>
<term>Other dogs</term>
<term>Other phenanthrenemethanol</term>
<term>Peak frequency</term>
<term>Phenanthrenemethanols</term>
<term>Polyethylene glycol</term>
<term>Pulmonary compliance</term>
<term>Pulmonary resistance</term>
<term>Rabbits</term>
<term>Sadavongvivad</term>
<term>Serotonin</term>
<term>Serotonin content</term>
<term>Serotonin level</term>
<term>Significant change</term>
<term>Therapeutic index</term>
<term>Total dose</term>
<term>Ventricular fibrillation</term>
<term>Vivax malaria</term>
<term>Walter reed army institute</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Anesthésie</term>
<term>Animaux</term>
<term>Aorte</term>
<term>Biochimie de l'encéphale</term>
<term>Bronches</term>
<term>Chloroforme</term>
<term>Coeur</term>
<term>Compliance pulmonaire</term>
<term>Débit cardiaque</term>
<term>Lapins</term>
<term>Mâle</term>
<term>Poumon</term>
<term>Pression sanguine</term>
<term>Résistance vasculaire</term>
<term>Souris</term>
<term>Électrocardiographie</term>
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<front><div type="abstract" xml:lang="en">Abstract: WR 33,063 has the chemical name: 6-bromo-α-(diheptylaminomethyl)-9-phenanthrenemethanol. It does not influence the cardiac output, blood pressure and pulmonary resistance in anesthetized dogs. It does not influence pulmonary resistance or blood pressure in anesthetized rabbits. The compound depresses the excitability of the heart of mice in response to inhalation of chloroform. There are no important changes in contents of biogenic amines in the lung, heart, and brain of mice and rabbits that receive doses less than 100 mg/kg of WR 33,063. The other phenanthrenemethanol which has been previously investigated in man is NIH 204; it has the following chemical name: α-(diamylaminomethyl)-1,2,3,4-tetrahydro-9-phenanthrenemethanol. This compound produces an increase in pulmonary resistance in anesthetized rabbits and dogs. It also increases cardiac output in dogs by releasing catecholamines. The mechanism for the previously reported sympathomimetic effect of NIH 204 in man has been identified in the experiments in dogs; this compound causes a release of catecholamines.</div>
</front>
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<region><li>Pennsylvanie</li>
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<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Ruiz, Ruy" sort="Ruiz, Ruy" uniqKey="Ruiz R" first="Ruy" last="Ruiz">Ruy Ruiz</name>
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<name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name>
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